Griffithsin patent

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August undefined, 2024

WebAug 23, 2016 · Griffithsin Gel is a large biologic molecule that is intended for vaginal rather than systemic administration. In addition, Griffithsin Gel is being developed for the prevention of HIV infection and not as a therapeutic agent. The concentration of Griffithsin Gel associated with prevention of HIV in vitro and in vivo has been established in non ... Webgriffithsin cov sars protein infection Prior art date 2024-08-24 Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Pending Application number CN202410867243.0A Other languages English (en) Inventor ...

Griffithsin - Wikipedia

WebA safe and effective topical microbicide against HIV is urgently needed to prevent sexual transmission. Hence, we evaluated griffithsin (GRFT), a 12.7 kDa carbohydrate-binding … WebAug 10, 2010 · U.S. Provisional Patent Application Serial No. 60/741.403, filed on Start Printed Page 48356 December 1, 2005, ... Griffithsin is a novel, potent anti-HIV protein … crisp ditchingham

Griffithsin tandemers: flexible and potent lectin inhibitors of the ...

WebJul 25, 2024 · Griffithsin, or "GRFT", is an investigational product that is being developed as a microbicide. GRFT is a naturally occurring protein originally isolated from the red alga Griffithsia found in the South Pacific Ocean. GRFT is one of the most powerful, broad-spectrum antivirals ever tested and its activity is under study for potential ... WebApr 19, 2024 · Patent number: 11339195. Abstract: The invention provides modified griffithsin polypeptides comprising the amino acid sequence of SEQ ID NO: 1, as well … WebFeb 7, 2011 · US Patent for Griffithsin, glycosylation-resistant griffithsin, and related conjugates, compositions, nucleic acids, vectors, host cells, methods of production and methods of use Patent (Patent # 8,394,764 issued March 12, 2013) - Justia Patents Search bud whillock photography

Frontiers Technoeconomic Modeling of Plant-Based Griffithsin ...

US Patent for Griffithsin, glycosylation-resistant griffithsin, and ...

WebFeb 10, 2016 · The invention provides modified griffithsin polypeptides comprising the amino acid sequence of SEQ ID NO: 1, as well as corresponding nucleic acids, vectors, cells, … The prospective exclusive patent license will include terms for the sharing of royalty income with NCI from commercial sublicenses of the patent rights and may be granted unless within fifteen (15) days from the date of this published notice the NCI receives written evidence and argument that establishes that the grant of the license would not ... bud white athens alWebJan 23, 2015 · The lectin griffithsin (GRFT) is a potent antiviral agent capable of prevention and treatment of infections caused by a number of enveloped viruses and is currently under development as an anti-HIV microbicide. bud wheel socket at napa

"WebJul 19, 2024 · The formulations for Q-griffithsin were originally developed as a possible preventative for HIV. However, after watching the COVID-19 pandemic escalate, the research team looked back at previous... " - Griffithsin patent

Griffithsin patent

PREVENT-COVID-19: A Q-Griffithsin Intranasal Spray

WebJan 23, 2016 · Protein microbicides containing neutralizing antibodies and antiviral lectins may help to reduce the rate of infection with human immunodeficiency virus (HIV) if it is possible to manufacture the components in large quantities at a cost affordable in HIV ‐endemic regions such as sub‐Saharan Africa. We expressed the antiviral lectin … WebThe crystal structure of griffithsin, an antiviral lectin from the red alga Griffithsia sp., was solved and refined at 1.3 A resolution for the free protein and 0.94 A for a complex with mannose. Griffithsin molecules form a domain-swapped dimer, in which two beta strands of one molecule complete a …

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WebJan 6, 2024 · This is a phase 1 study for intranasal application of Q-Griffithsin (Q-GRFT) spray as a prophylactic for severe acute respiratory syndrome-CoV-2. This randomized, placebo-controlled, single site will assess the local and systemic safety of intranasal Q-GRFT after 14 doses in approximately 45 adult participants. Webparticular molecule carries no net electrical charge) of the modified griffithsin polypeptides can optimize the bioavailability of the modified griffithsin polypeptides in different compartments of the body (e.g., nasal cavity, lung, gut, small intestine, colon, blood, vagina, and rectum). The pH of wild-type griffithsin of SEQ ID NO: 2 is 5.1.

WebAug 2, 2011 · Many natural product-derived lectins such as the red algal lectin griffithsin (GRFT) have potent in vitro activity against viruses that display dense clusters of … WebThe results show that griffithsin is potently active (sub-nanomolar EC 50 values) against a broad range of HIV isolates including T-tropic viruses (utilizing CCR5 as a co-receptor) and M-tropic viruses (utilizing CXCR4 as a co-receptor). This picomolar level of activity is more potent than that described for most of the current anti-HIV agents utilized in therapy or in …

WebJul 8, 2024 · The patent rights for this technology cover the sequence of the GRFT polypeptide as well as several GRFT variants mutated to render them glycosylation … WebUS8394764B2 - Griffithsin, glycosylation-resistant griffithsin, and related conjugates, compositions, nucleic acids, vectors, host cells, methods of production and methods of use - Google...

WebNov 16, 2024 · Detailed Description: Q-Griffithsin (Q-GRFT) nasal spray is an investigational product that has broad spectrum antiviral activity. Q-GRFT is derived from …

WebU.S. Patent Application 20240087359 for Griffithsin Mutants Griffithsin Mutants O'Keefe; Barry R. ; et al. [The United States of America,as represented by the Secretary,Department of Health and Human Services] crisp-dm sdlc researchWebNov 4, 2024 · Griffithsin (GRFT) is a high-mannose oligosaccharide-binding lectin currently being evaluated in phase I clinical trials as a topical microbicide for the prevention of human immunodeficiency virus (HIV-1) … crisp dill pickles with alumWebJul 14, 2024 · A “Swiss army knife” protein that is active against several viruses may also offer some protection against Nipah virus, a lethal pathogen with no cure or vaccine. The “tool” is griffithsin, a compound extracted from the red algae Griffithsia. A modified version of the protein substantially increased survival rates when administered as a preventative … bud whiteheadWebJul 24, 2024 · Griffithsin is a marine algal lectin that exhibits broad-spectrum antiviral activity by binding oligomannose glycans on viral envelope glycoproteins, including those found in HIV-1, HSV-2, SARS, HCV and other enveloped viruses. crispeats715WebNov 16, 2024 · This is the first-in-human clinical study to see if a single dose of an investigational nasal spray made from a modified plant protein called Q-Griffithsin is safe, tolerated and acceptable for use by healthy adults 18 to 60 years of age. bud wheel socket and wrenchWebJan 23, 2015 · The lectin griffithsin (GRFT) is a potent antiviral agent capable of prevention and treatment of infections caused by a number of enveloped viruses and is currently … bud wheel toolWebInterPro. Griffithsin is a protein isolated from the red algae Griffithsia. It has a 121- amino acid sequence [2] which exhibits a Jacalin-like lectin fold. Several structures of this … crisp dm methode