Clozapine related hypersalivation
WebJul 1, 1998 · With clozapine, drooling and pillow wetting presumably result from increased saliva production (hence, the usual descriptors, “hypersalivation” and “sialorrhea”), … WebScale and the Drooling Severity and Frequency Scale were used. Results: Clozapine-induced hypersalivation was experienced by 92% of participants, with nocturnal …
Clozapine related hypersalivation
Did you know?
WebOct 1, 2011 · Hypersalivation is a well-documented side effect of clozapine that may affect nearly 30% of patients who take this medication. 1 Because clozapine has anticholinergic properties that are expected to reduce secretions, hypersalivation is considered a paradoxical effect. This paradox can be explained by examining clozapine’s actions at … WebIs clozapine-induced hypersalivation dose-related? Although hypersalivation in some patients may be improved by dose reduction it is not necessarily dose-related.12,13 Reinstein et al13 reviewed 1000 clozapine patients to identify those with adverse effects and then reduced clozapine dose while adding quetiapine.
WebA guide to the management of clozapine-related tolerability and safety concerns. / Citrome, Leslie; McEvoy, Joseph Patrick ... can be mitigated with regular monitoring and timely interventions. Sedation, hypersalivation, and enuresis are common but manageable with ameliorative measures and/or medications.", keywords = "Adverse events, … WebSep 4, 2024 · Hypersalivation occurs towards the beginning of treatment in some 30–80% of patients given clozapine. It may be dose-related and/or due to disruption of the swallowing reflex. It is especially troublesome at night. Tolerance often develops, but if not reduce the dose if possible, then if necessary, increase the dose more slowly than before.
WebSep 22, 2024 · Evidence is scarce for clozapine-related hypersalivation and constipation treatment [41, 49, 115] (see Fig. 4A, B).
WebBackground and objective: Hypersalivation is a common, clozapine-related adverse drug reaction with a serious impact on quality of life. Pharmacokinetic correlates of clozapine …
WebHypersalivation is a common and well-known adverse effect of clozapine, and the use of antimuscarinic agents, adrenoceptor antagonists, and adrenoceptor agonists has been proposed (SED-15, 831; SEDA-29, 68). In 12 patients clonidine 50–100 micrograms/day relieved clozapine-induced sialorrhea, with good results in three and partial results in ... top ten best coffee beansWebclozapine-related agranulocytosis by facilitating a replen-ishment of precursors of granulocytes and macrophages in ... probably the second most common side effect of clozapine treatment.25 Since hypersalivation commonly occurs at night, a history can often be elicited by asking if the patient’s pillow is wet upon arising. Research indicates top ten best cheap laptopsWebcessful control of hypersalivation using pirenzepine, at daily doses of 25 mg to 100 mg (Table 1). Cardiovascular and Respiratory Effects Tachycardia (25%) and hypotension (9%) are the most common cardiovascular side effects of clozapine. Although it may be related to hypotension, clozapine-associated top ten best cigarsWebHypersalivation is a common and well-known adverse effect of clozapine, and the use of antimuscarinic agents, adrenoceptor antagonists, and adrenoceptor agonists has been … top ten best chinese martial arts moviesWebClozapine-induced hypersalivation is the most prevalent adverse effect experienced by patients treated with clozapine and negatively impacts on quality of life,1 with symptoms … top ten best chess openingsWebObjective: Clozapine-induced hypersalivation (CIH) is a significant side effect affecting about one-third of patients treated with clozapine. CIH can be stigmatizing, can affect … top ten best christmas movies of all timeWebAug 9, 2024 · The search resulted in a list of 236 articles. Eighty-three articles related to clozapine-induced sialorrhoea were excluded. ... and Lan TH. Treatment effects of traditional Chinese medicines Suoquan Pill and Wuling Powder on clozapine-induced hypersalivation in patients with schizophrenia: study protocol of a randomized, placebo … top ten best chess players